How far down the path have we gone?

Corruption in medical practice: how far have we gone?

The neurohormonal paradigm: have we gone too far?

Following success with adrenergic blockade and inhibition of the renin-angiotensin-aldosterone axis, many physicians have believed that blockade of other neurohormonal systems will also prove to be beneficial in patients with heart failure (HF). However, recent data suggest that it is time to change our conception of how to improve survival and symptoms in these patients. We have seen that anta...

Pharmaceutical services and health promotion: how far have we gone and how are we faring? Scientific output in pharmaceutical studies

The objective of this study was to investigate the scientific output on health promotion within the pharmaceutical field and its relation with the development of pharmaceutical services within health systems. A comprehensive review of published scientific articles from the Medline and Lilacs databases was carried out. The review comprised articles published until December 2011, and used combina...

Computer Assisted Surgery for Iliosacral Screw Placement-How Far have we gone?

Unstable pelvic ring injuries require definite operative fixation. While the posterior ring can be fixed utilizing open approaches, percutaneous screw fixation has become the treatment of choice avoiding the complications of open approaches. As the pelvis is a complex three-dimensional (3D) shape with many neurovascular structures situated within it, a thorough knowledge and understanding of th...

Association of Small-Conductance Calcium-Activated Potassium Channels and Atrial Fibrillation - How Far Have We Gone?

UNLABELLED Atrial fibrillation (AF) is the most common sustained and most important arrhythmia in clinical practice. The mechanisms underlying AF initiation and maintenance are known to be complex and heterogeneous. The general understanding of the detailed molecular basis of AF is still incomplete. Recently, these is increasing evidence that small conductance calcium-activated potassium (SK) c...